Epigallocatechin gallate (EGCG) is an ingredient extracted from Chinese green tea. It is the main active and water-soluble component of green tea and the component with the highest content among catechins, accounting for 9%-13% of the gross weight of green tea. Due to its special stereochemical structure, EGCG has very strong antioxidant activity, which is at least 100 times that of vitamin C and 25 times that of vitamin E. It can protect cells and DNA from damage, which is believed to be related to cancer, heart disease and other major diseases. These effects of EGCG are attributed to their ability to scavenge (antioxidant) oxygen free radicals.
Epigallocatechin gallate plays an important role in anti-cancer and cardiovascular disease. In addition, it is also used as a reversal agent for tumor multidrug resistance, which can improve the sensitivity of cancer cells to chemotherapy and reduce toxicity to the heart.
EGCG is the main component of green tea polyphenols and the main component of green tea catechins. Catechins include EGCG, EGC, ECG, EC, GCG, etc., among which the antioxidant activity is EC in the following order. Many studies have shown that EGCG has the effects of resisting free radical DNA damage, resisting radiation and ultraviolet rays, preventing lipid peroxidation, reducing the levels of low-density cholesterol, ultra-low-density cholesterol and triglycerides in serum, interfering with the signal transmission required for the survival of cancer cells, inhibiting carcinogens in the diet, and working together with other enzymes and antioxidants in the intestines, liver, and lungs to block the activity of certain carcinogens, scavenge free radicals, resist the effects of pollution, sun exposure and smoking, and prevent and treat skin aging and wrinkling.
application
1. In medicine and health care, it has the functions of preventing and treating cancer and other diseases and enhancing immunity.
The anti-tumor effect of EGCG has been recognized by relevant researchers in various countries, and it has been listed as a potential new anti-cancer drug and is being studied in many countries including China and the United States. A large number of clinical medical experiments have shown that EGCG is as effective as paclitaxel in treating various cancers, but its toxicity is far lower than paclitaxel. In particular, there are many research reports on its application in skin cancer, and it has now entered the clinical stage. It can be said that it is an effective, non-toxic and ideal drug for treating cancer and has great development value.
The main pharmacological effects of EGCG are:
⑴Inhibit the invasion and metastasis of tumor cells;
⑵Adjust the metabolic process of tumor initiators;
⑶ Regulate carcinogen metabolizing enzymes;
(4) Inhibit the covalent binding of oncogenes and DNA;
⑸Inhibit the proliferation of tumor cells;
(6) Inhibit the nitrosation process;
⑺ Significant anti-oxidation, free radical scavenging, and anti-mutagenic effects can enhance the immune system, inhibit the growth of liver fat and cholesterol, inhibit tumor growth, and have strong effects on bacteria such as dysentery, typhoid, and Staphylococcus aureus. Inhibitory effect.
EGCG also has anti-aging, lipid-lowering, improving low-density lipoprotein, preventing atherosclerosis, and enhancing immunity; it can inhibit the proliferation of glomerular cell membranes and improve renal function; it can effectively inhibit hyaluronidase, reduce inflammation and allergy.
2. It can be used as an antioxidant, antibacterial, fresh-keeping and deodorizing agent in the food industry
3. Used as a preservative and skin care agent with special functions in daily chemical products
At room temperature, low concentration of EGCG has strong antioxidant, free radical elimination, sterilization and deodorization functions, so adding a small amount of EGCG can prevent the deterioration of cosmetics. As a natural biochemical raw material for cosmetics, EGCG has the following characteristics compared with other biochemical raw materials: small molecular weight, easy to be absorbed by human skin, good transdermal absorption performance; extremely stable activity, temperature has little effect on its activity change, Under acidic and light-proof conditions, the activity remains unchanged for a long time; safe and reliable, tested by relevant professional institutions, its toxicological determination and micronucleus test show that it is a non-toxic and non-irritating substance, which meets the quality standards of daily chemical products; small dosage, Strong effect; it has strong antioxidant activity, its antioxidant capacity is 2-4 times that of DHA and BHT, and it is effective at low concentrations.
The role of EGCG in cosmetics is summarized as follows:
⑴ Anti-wrinkle and beauty effects;
⑵Sunscreen and spot removal effect;
⑶ Eliminate the toxic effects of heavy metals;
⑷ Antibacterial and anti-inflammatory effects;
⑸ Promote skin microcirculation, etc.;
⑹ Anti-skin cancer;
⑺It can eliminate skin freckles and yellow spots and make the skin smooth.
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