Triptonide, also known as triptonone, is a substance extracted from the whole plant or peeled woody part of Tripterygium wilfordii, a plant of the Celastraceae family.
Triptonide, CAS number 38647-11-9, molecular formula C₂₀H₂₂O₆, molecular weight 358.39.
Physical and chemical properties: It is a grayish white to light beige solid, melting point 251℃-252℃, boiling point 581.1±50.0°C, density 1.48±0.1g/cm³, soluble in methanol, ethanol, DMSO and other organic solvents.
Purity: more than 99%, detection method HPLC.
Storage conditions: It needs to be stored in a dry, moisture-proof and moth-proof environment.
Effects of Triptonide
Immunosuppressive effect: Triptonide can inhibit the activity of immune cells, reduce the production of immunoglobulins, and thus exert immunosuppressive effects. In the treatment of some autoimmune diseases, the purpose of alleviating the condition can be achieved by regulating the overreaction of the immune system, such as rheumatoid arthritis.
Anti-inflammatory effect: It can inhibit the release of inflammatory mediators and effectively reduce inflammatory reactions. It has certain therapeutic potential for a variety of inflammatory-related diseases, such as inflammatory reactions caused by rheumatoid arthritis and nephritis, which helps to reduce patients' joint pain, swelling, and inflammatory damage to the kidneys.
Anti-tumor effect: Studies have found that triptolide has an inhibitory effect on the growth and proliferation of tumor cells, can interfere with the metabolic process of tumor cells, and induce tumor cell apoptosis. It is expected to become an important candidate compound for the development of new anti-tumor drugs and provide new ideas and methods for the treatment of cancer.
Anti-fertility effect: Triptolide has male anti-fertility effects and is a potential non-hormonal male contraceptive. Its mechanism of action may be to achieve the contraceptive effect by affecting the production, development and function of sperm, but the relevant research is still in the basic stage and needs further exploration and verification.
Neuroprotective effect: In terms of nervous system diseases, triptolide shows certain neuroprotective activity, which may protect nerve cells through anti-oxidation and anti-apoptosis pathways, providing a new direction for the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
Triptonide, CAS number 38647-11-9, molecular formula C₂₀H₂₂O₆, molecular weight 358.39.
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