The Function of Phloretin
1. Anti-oxidation and anti-free radical effects
Phloretin has strong oxidation resistance, and its antioxidant concentration for oil is between 10 and 30 ppm, which can remove free radicals in the skin. Free radicals are harmful substances produced by oxidation reaction, which are related to human degenerative diseases. External use can prevent saccharides from entering epidermal cells, thus inhibiting excessive secretion of sebaceous glands and treating acne with exuberant secretion.
Phloretin can inhibit the activity of melanocytes and dilute various skin spots. Phloretin is a new natural skin whitening agent, often used in facial masks, creams, lotions and serums. It can inhibit the excessive secretion of sebaceous glands and is used to treat acne with strong secretion. It can inhibit the activity of melanocytes and has an effect on various skin stains. Compared with similar natural ingredients arbutin and kojic acid, the same concentration of phloretin has a better inhibitory effect on tyrosinase, and when it is combined with arbutin or kojic acid, it can greatly improve the inhibitory rate of tyrosinase, so as to achieve whitening effect. Phloretin has a particularly strong moisturizing effect, which can absorb 4-5 times the water of its own weight, and can promote the absorption of other functional factors in the formula, so that it can play a better effect; Its antioxidant capacity is also very strong, can remove free radicals in the skin.
2. Anti-inflammatory and immunosuppressive effects
The results showed that under the action of phloretin, the amount of NO released by macrophages under the stimulation of inhibiting lipopolysaccharide and IFN-γ decreased obviously. The phagocytosis rate of megalithic cells also decreased obviously under the action of phloretin. Therefore, phloretin has potential anti-inflammatory effect.
In the aspect of immunosuppression, phloretin is a competitive inhibitor of sodium D- glucose cotransporter. Because it can increase the fluidity of lipid bilayer in cells, it can increase the types and activities of drugs transported across the membrane.
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