Sophora flower bud extract is derived from the dried flower buds of the leguminous plant Sophora japonica L. Sophora japonica is produced in most parts of my country. It is usually harvested in summer when the flower buds are formed and used for extraction after drying. Its extract is obtained from Sophora japonica through various extraction processes.
Ingredients of sophora flower bud extract
The main components of Sophora japonica extract are flavonoids. Among them, rutin is the component with the highest content, which can reach about 20% - 40%. Rutin belongs to flavonol glycosides and has strong physiological activity.
It also contains quercetin, which is the aglycone of rutin. Under certain conditions, rutin can be hydrolyzed to form quercetin. In addition, there are a small amount of triterpenoid saponins, polysaccharides and other flavonoids, such as isorhamnetin, etc. These components together constitute the complex component system of Sophora japonica extract.
Efficacy of sophora flower bud extract
Antioxidant effect
Flavone compounds in Sophora japonica extract are key antioxidant components. Flavonoids such as rutin can scavenge a variety of free radicals, including superoxide anion free radicals, hydroxyl free radicals and lipid peroxidation free radicals.
Its antioxidant mechanism is mainly to provide hydrogen atoms or electrons to convert free radicals into more stable products, thereby terminating the chain reaction caused by free radicals. It plays an important role in preventing cell oxidative damage, for example, it can reduce cell aging and death caused by oxidative stress, and has potential value in preventing chronic diseases such as cardiovascular disease and cancer.
Anti-inflammatory effect
Flavonoids play a key role in the anti-inflammatory process. They can inhibit the production of inflammatory mediators in inflammatory cells, such as inhibiting the synthesis of nitric oxide (NO) and prostaglandin E2 (PGE2). At the same time, it can also inhibit the activity of inflammatory-related enzymes, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).
For inflammatory diseases such as arthritis and enteritis, Sophora japonica extract can reduce the redness, pain and tissue damage caused by inflammation, and may improve the inflammatory response by regulating the function of immune cells.
Vascular protection effect
Rutin can enhance the toughness and elasticity of blood vessel walls. It can reduce the permeability of capillaries and reduce the exudation of intravascular substances, and has a good effect on the prevention and treatment of diseases such as microvascular bleeding.
At the same time, Sophora japonica extract can also reduce the cholesterol and triglyceride levels in the blood, inhibit platelet aggregation, reduce the risk of thrombosis, and play a positive role in preventing cardiovascular diseases such as atherosclerosis.
Anti-cancer effect
Some components in Sophora japonica extract have shown anti-cancer potential in in vitro experiments and some animal experiments. Its mechanism may be through inducing tumor cell apoptosis, inhibiting tumor cell proliferation and migration, and other pathways.
For example, rutin can regulate signaling pathways in tumor cells, such as inhibiting the PI3K-AKT signaling pathway, so that the growth of tumor cells is inhibited. However, there are relatively few studies on human clinical trials, and more research is needed to confirm its anti-cancer effect.
Application of sophora flower bud extract
Medical field
In traditional Chinese medicine, Sophora japonica extract is often used to treat bleeding diseases such as blood in stool and hemorrhoids, and is an important medicinal material for cooling blood and stopping bleeding. In modern medicine, its antioxidant, anti-inflammatory and vascular protection properties can be used to develop drugs for the treatment of cardiovascular diseases (such as coronary heart disease, hypertension, etc.).
It can also be used as an auxiliary therapeutic drug for the treatment of inflammatory diseases and cancer, and used in combination with other drugs to enhance the therapeutic effect.
Food industry
Sophora japonica extract can be used as a natural food additive for the development of functional foods and health foods. When added to beverages, pastries and other foods, its antioxidant function can be used to extend the shelf life of food, while giving food certain health functions.
Cosmetics industry
Sophora japonica extract is used in cosmetics, mainly for its antioxidant and anti-inflammatory properties. In skin care products (such as creams, lotions, essences, etc.), it can prevent skin aging, reduce skin inflammation, and improve skin luster and elasticity. In sunscreen products, it can also enhance the ability to protect against ultraviolet rays and reduce ultraviolet damage to the skin.
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