Sodium dichloroacetate is a chemical substance with the molecular formula C2HCl2NaO2.
Melting point: 198ºC (DEC.)
Water solubility: soluble INCOLDWATER
Description: Slightly yellow to white crystalline powder, melting point 189-192℃.
Sodium dichloroacetate can be used as an anti-tumor drug for the treatment of tumors.
Sodium dichloroacetate is a white solid powder at room temperature and pressure. It has a certain alkalinity and strong hygroscopicity. It has good solubility in water and is soluble in alcohol organic solvents. Sodium dichloroacetate is a medicinal ingredient. In clinical practice, this substance is often used to treat diseases such as lactic acidosis (LA) and can be injected intravenously or orally.
Basic Introduction
Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor with potent anti-leukemia activity. Sodium dichloroacetate is a metabolic regulator in cancer cell mitochondria with anti-cancer activity. The substance inhibits pyruvate dehydrogenase kinase (PDHK), resulting in a decrease in lactate in the tumor microenvironment. In addition, it increases the production of reactive oxygen species (ROS) and promotes apoptosis of cancer cells, and can also act as an NKCC inhibitor.
Uses
Sodium dichloroacetate can be used as a basic chemical in inorganic chemistry, it can be used as an organic salt precursor for the synthesis of microporous carbon, it can be used to develop carbon-based adsorbents, and the substance can also be used as a sodium carboxylate salt in the field of chemical synthesis. In addition, sodium dichloroacetate has been used as a drug for the treatment of congenital mitochondrial diseases, and the research done by Peter Staple and his colleagues has shown that sodium dichloroacetate does not cause any, mild or moderate side effects when used to treat congenital mitochondrial diseases.
Directions for use
If patients are currently using cannabinoids, benzodiazepines, opioids, or other drugs that affect the central nervous system, keep in mind that DCA can amplify adverse effects caused by these drugs (e.g., delirium, memory problems). This is more likely to happen if the prescription is already causing side effects. DCA appears to have a positive effect on heart function without creating an additional demand for oxygen. It also improves the efficiency of energy production in the heart muscle. The drug can be safely used in people with heart failure and increased risk of cardiac ischemia. Diabetic patients can achieve better blood sugar control with the help of sodium dichloroacetate, which appears to lower blood sugar between meals.
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