What are Senolytics?
The word senolytics, which means "fighting aging," is now used to refer to a class of chemical ingredients that may help support the healthy aging process. As such, senolytics are a general term for a class of nutrient-rich substances that are often used to fight or protect against age-related diseases.
A study using mice showed that senolytics may help extend lifespan.
Most studies investigating the mechanisms of action of senolytics show that they work in a variety of ways. One of the main effects of senolytics is the targeted removal of senescent cells. Senescent cells are old cells in the body that no longer function properly.
Cell senescence can be caused by cell damage, genes that cause malignant cell mutations, DNA damage, or shortened telomeres.
As the body ages, senescent cells may accumulate in the body. These cells then stop proliferating, but they may also refuse to die. Apoptosis is a natural phenomenon in which old cells undergo programmed death so that new cells can take their place.
However, if aging "zombie" cells refuse to die, they may not only secrete harmful proteins, cause inflammatory reactions, and cause tissue damage, but also greatly increase the probability of chronic diseases and other diseases. Many studies attribute the onset of various diseases to the accumulation of senescent cells. Cardiovascular disease, metabolic dysfunction, kidney disease, malignant cell mutations, and even senile frailty may be closely related to aging "zombie" cells. Studies have shown that anti-aging supplements may help reduce senescent cells.
Here are 6 anti-aging supplements that help healthy aging.
1. Fisetin
When it comes to anti-aging supplements, Fisetin is one of the most important star ingredients. Fisetin is a plant flavonoid composed of a naturally occurring molecule that is found in a variety of fruits and vegetables.
Some foods rich in Fisetin include strawberries, apples, tomatoes, and cucumbers.
Studies have shown that Fisetin may have effective anti-aging activity.
In a test-tube study, human fat tissue was used to test the effectiveness of fisetin as an anti-aging remedy. The study found that fisetin may help clear zombie-like senescent cells from human fat tissue, thereby reducing the overall number of senescent cells in the body.
The study also tested the effects of fisetin on aged mice. The study concluded that supplementing with fisetin may help extend the lifespan of mice while restoring the internal balance of organs and reducing age-related diseases.
Studies have shown that fisetin may also have anti-inflammatory effects. A test-tube study found that fisetin may inhibit the secretion of inflammatory cytokines, or cell messengers.
Overall, fisetin may help reduce zombie cells and has significant anti-inflammatory properties, making it a potential ingredient in supporting healthy aging.
2. Apigenin
Similar to fisetin, apigenin is a flavonoid compound that occurs naturally in foods such as parsley, celery, artichokes, and chamomile.
Studies have shown that apigenin may also be a very effective anti-aging supplement. A test-tube study found that apigenin may inhibit the secretion of harmful proteins by senescent cells.
Studies have shown that harmful proteins secreted by senescent cells may not only increase inflammation, but also turn healthy cells into zombie cells.
Studies have shown that apigenin, as a reliable anti-oxidant, may help the body produce more glutathione.
Studies have shown that glutathione is a major anti-oxidant in the human body. Glutathione may play an important role in protecting cells from oxidative stress. In addition, glutathione may help protect cells from toxic damage caused by external ingested substances such as prescription drugs.
As the body ages, the amount of glutathione in the body decreases, and the oxidative stress response continues to increase.
3. Quercetin
When it comes to anti-aging supplements, quercetin is also a powerful ingredient that cannot be ignored. Similar to fisetin and apigenin, quercetin is also a naturally occurring flavonoid compound. Some foods that contain quercetin include onions, broccoli, apples, and cherries.
In an open-label, phase 1 pilot study, nine subjects diagnosed with glycometabolism nephropathy were followed after taking quercetin and a prescription.
The nine subjects were both male and female, ranging in age from 68 to 71 years old. In the study, the subjects took quercetin and dasatinib for 3 consecutive days, and the number of senescent cells in fat tissue was measured 11 days later.
The study found that the combination of quercetin and dasatinib may significantly reduce the number of senescent cells in fat tissue. The study also found that the combination of quercetin and the above prescriptions may relieve inflammation by reducing the secretion of inflammatory cell messengers.
Another review pointed out that quercetin supplementation may also help protect the heart from heart failure associated with age.
4. Curcumin
Curcumin comes from turmeric, a golden spice, and is the main bioactive compound in it. Recent studies suggest that curcumin may have a number of health-promoting properties, ranging from potent effects that may reduce inflammation to significant activity against malignant cell mutations.
Research is increasingly making it clear that curcumin may also serve as a compelling anti-aging agent. Animal studies have found that curcumin may have antioxidant properties that help fight disease and extend life.
One animal study found that curcumin supplementation may extend the average lifespan of Wistar rats by nearly 40%.
Another animal study on the nematode Caenorhabditis elegans found that curcumin supplementation may extend the lifespan of the nematode by more than 20%. The lifespan of C. elegans is usually 12-18 days. The study showed that curcumin supplementation could extend the lifespan of the nematode by more than 3 days.
Studies have shown that curcumin may have a lifespan-promoting effect by optimizing the activity of an enzyme in the human body that may have the activity to maintain healthy telomere length. Telomeres are the ends of DNA. As we age, our telomeres get shorter.
Shorter telomere lengths may be associated with an increase in age-related diseases and a shorter lifespan.
5. Milk Thistle
Silver thistle (Silybum marianum), also known as milk thistle, is another anti-aging supplement that has shown significant efficacy. Milk thistle is an herbaceous plant in the genus Silybum, in the Asteraceae family, and is more or less related to the daisy family. Milk thistle is native to the Mediterranean region and is now grown and used in prescriptions around the world.
This particular herbal remedy is often used to improve liver and gallbladder health, but research suggests that milk thistle may also be used as an anti-aging supplement. In a test-tube study,
Milk Thistle Extract was introduced into aged human skin cells.
The study showed that aged skin cells hinder the growth and proliferation of young skin cells. Senescent cells also cause normal skin cells to enter a zombie state.
The study found that milk thistle extract may help remove aged skin cells and help young skin cells proliferate. Studies have concluded that milk thistle may rejuvenate skin cells and slow premature aging.
In addition to its potential anti-aging properties, research suggests that milk thistle may also act as an active anti-oxidant, providing benefits ranging from supporting metabolism to helping maintain normal blood pressure.
6. Green Tea Extract EGCG
Epigallocatechin gallate, or EGCG, may also have health benefits for the aging process.
EGCG is a flavonoid compound commonly found in green tea. It has been used and recognized as a natural alternative medicine in medical traditions around the world for centuries. Research suggests that EGCG may have some anti-aging activity. One test-tube study found that EGCG may help improve mitochondrial dysfunction by supporting the growth of new mitochondria.
Mitochondria are the powerhouses of cells. They generate the energy needed for the body to function properly.
As we age, mitochondrial function tends to decline, leading to reduced energy and physical weakness.
Research shows that EGCG can also help the body age normally and healthily as a defensive oxidative component. A test-tube study found that EGCG may help synthesize proteins that have anti-aging and longevity functions by weakening oxidative stress.
EGCG may also have the excellent properties of relieving inflammation and resisting malignant cell mutations.
Couclusion
Anti-aging supplements, as a wonderful class of molecular substances, may bring incredible benefits by helping to clean up zombie cells in the body and allowing the body to enter the aging process more healthily and steadily. Research shows that many natural anti-aging prescriptions may also have other positive effects, such as relieving inflammation or defending against oxidation.
For those of you who pay attention to health and want to age gracefully, you may wish to include anti-aging supplements in your daily nutritional supplement plan, which may help you achieve good health and prolong your life in the coming years.
