Adenosylcobalamin can usually replace methylcobalamin under certain circumstances. The chemical structures of the two drugs are similar. Both are derivatives of vitamin B12 and can treat some anemia diseases and neuropathy.
1. Adenosylcobalamin: Adenosylcobalamin can promote the growth and development of red blood cells. It is suitable for the treatment of megaloblastic anemia, malnutrition anemia, anemia during pregnancy and other anemia diseases. It can also promote nerve formation and has a certain effect of nourishing nerves. Therefore, it can also be used to treat trigeminal neuralgia, radiculitis, nerve paralysis and other neuropathy. In addition, adenosylcobalamin mainly produces a nutritious nerve effect in the body and can be used in place of methylcobalamin;
2. Methylcobalamin: It is mainly used to treat peripheral neuropathy, which can help improve the conduction of neurons and repair damaged nerve tissue. For the treatment of nervous system diseases, the effect of methylcobalamin is slightly stronger than that of adenosylcobalamin.
However, it is not recommended to replace drugs without authorization. Before using adenosylcobalamin to replace methylcobalamin, it is recommended to consult a doctor for specific usage and dosage.
Adenosylcobalamin is an organic compound with the chemical formula C72H99CoN18O17P. It is a vitamin B12 coenzyme and is mainly used for megaloblastic anemia, nutritional anemia, and anemia during pregnancy. It is also used for neurological diseases such as multiple neuritis, radiculitis, trigeminal neuralgia, sciatica, nerve paralysis, nutritional neurological diseases, and leukocytopenia caused by radiation and drugs.
Pharmacology
Adenosylcobalamin is a congener of cyanocobalt vitamin B12, that is, its cyano group is replaced by adenine nucleoside to become 5'-deoxyadenosylcobalamin. It is one of the two active coenzyme forms of vitamin B12 in the body and is a substance necessary for cell growth and reproduction and maintaining the integrity of the myelin sheath of the nervous system. It is absorbed rapidly and completely after intramuscular injection, and the plasma concentration reaches a peak after 1 hour. It is stored in the liver and mainly excreted from the kidneys, most of which is excreted in the first 8 hours.
Indications
It is mainly used for megaloblastic anemia, nutritional anemia, and anemia during pregnancy. It is also used for neurological diseases such as multiple neuritis, radiculitis, trigeminal neuralgia, sciatica, nerve paralysis, nutritional nerve diseases, and leukopenia caused by radiation and drugs.
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